State University of New York at Buffalo (1983)
Professor, Clinical Psychology
Office Hours: Flexible, by appointment
Phone Number: (631) 632-7859
e-mail: daniel.klein@stonybrook.edu
Web site for Stony Brook temperament study: http://www.sbutemperamentstudy.org
Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early trauma and adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders and the processes responsible for comorbidity; and the psychotherapeutic and psychopharmacological treatment of mood disorders.
Current Research:
Dr. Klein is currently leading two large research projects. The first is a longitudinal study of the role of temperament and emotional style in the development of mood and anxiety disorders in a large sample of three-year children. The study uses multiple measurement strategies to assess potential risk and moderating factors in multiple domains, including child emotional reactivity and regulation; child psychopathology; parenting; parental psychopathology and personality; environmental and family stress; psychophysiological measures of emotional style and processing; neuroendocrine measures of stress reactivity; potential susceptibility genes; and neurocognitive measures of executive functioning and information processing biases.
The second project is part of a multi-site collaborative study examining the efficacy of augmenting medication with cognitive-behavioral psychotherapy in adult outpatients with chronic depression who have not responded to medication alone. The study is examining both the short-term and long-term effects of treatment, testing hypothesized meditational processes underlying response to psychotherapy (e.g., better problem-solving), and exploreing predictors of treatment response to medication and psychotherapy.
Selected Recent Publications:
Shankman, S.A., Klein, D.N., Tenke, C.E., & Bruder, G.E. (2007). Reward sensitivity in depression: A biobehavioral study. Journal of Abnormal Psychology, 116, 95-104.
Durbin, E.C., Hayden, E.P., Klein, D.N., & Olino, T.M. (2007). Stability of laboratory assessed temperament traits from ages 3 to 7. Emotion. 7, 388-399.
Dougherty, L.R., Klein, D.N., Olino, T.M., & Laptook, R.S. (2008). Depression in children and adolescents. In J. Hunsley & E. Mash (Eds.), A guide to assessments that work (pp. 69-95). New York: Oxford University Press.
Hayden, E.P., Dougherty, L.R., Maloney, B., Olino, T.M., Durbin, E.C., Sheihk, H.I., Nurnberger, Jr., J.I., Lahiri, D.K., & Klein, D.N. (2008). Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. Journal of Affective Disorders, 107, 227-230.
Klein, D.N. (2008). Classification of depressive disorders in DSM-V: Proposal for a two-dimension system. Journal of Abnormal Psychology, 117, 552-560.
Klein, D.N., Dougherty, L.R., Laptook, R.S., & Olino, T.M. (2008). Temperament and risk for mood disorders in adolescents.
In N. Allen and L. Sheeber (Eds.), Adolescent Emotional Development and the Emergence of Depressive Disorders (pp. 238-261). Cambridge, England: Cambridge University Press.
Klein, D.N., Shankman, S.A., & Rose, S. (2008). Dysthymic disorder and double depression: Baseline predictors of 10-year course and outcome. Journal of Psychiatric Research, 42, 408-415.
Klein, D.N., Torpey, D.C., Bufferd, S.J., & Dyson, M.W. (2008). Depressive disorders. In T.P. Beauchaine and S.P. Hinshaw (Eds.), Child and adolescent psychopathology (pp. 477-509). Hoboken, New Jersey: John Wiley & Sons.
Manber, R., Kraemer, H.C., Arnow, B.A., Trivedi, M.H., Rush, A.J., Thase, M.E., Rothbaum, B.O., Klein, D.N., Kocsis, J.H., Gelenberg, A.J., & Keller, M.B. (2008). Faster remission of chronic depression with combined psychotherapy and medication than with each therapy alone. Journal of Consulting and Clinical Psychology, 76 , 459-467.
Olino, T.M., Pettit, J.W., Klein, D.N., Allen, N.B., Seeley, J.R., & Lewinsohn, P.M. (2008). Influence of parental and grandparental major depressive disorders on behavior problems in early childhood: A three generation study. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 53-60.
Beauchaine, T.P., Klein, D.N., Crowell, S.E., Derbidge, C., & Gatzke-Kopp, L. (2009). Multifinality in the development of personality disorders: A biology × sex × environment interaction model of antisocial and borderline traits. Development and Psychopathology, 21, 735-770.
Klein, D.N., Arnow. B.A., Barkin, J.L., Dowling, F., Kocsis, J.H., Leon, A.C., Manber, R., Rothbaum, B.O., Trivedi, M.H., & Wisniewski, S.R. (2009). Early adversity in chronic depression: Clinical correlates and response to pharmacotherapy. Depression and Anxiety, 26, 701-710.
Klein, D.N., Durbin, C.E., & Shankman, S.A. (2009). Personality and mood disorders. In I.H. Gotlib & C.L. Hammen (Eds.), Handbook of Depression and Its Treatment (2nd ed) (pp. 93-112). New York: Guilford Press.
Klein, D.N., Shankman, S.A., Lewinsohn, P.M., & Seeley, J.R. (2009). Subthreshold depressive disorder in adolescents: Predictors of escalation to full syndrome depressive disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 703-710.
Rudolph, K.D., & Klein, D.N. (2009). Exploring depressive personality traits in youth: Origins, correlates, and developmental consequences. Development and Psychopathology, 21, 1155-1180.
Dougherty, L.R., Klein, D.N., Congdon, E., Olino, T.M., Dyson, M., Rose, S., & Canli, T. (in press). Increased waking salivary cortisol levels and depression risk in preschoolers: The role of maternal history of melancholic depression and early child temperament. Journal of Child Psychology and Psychiatry.
Kocsis, J.H., Gelenberg, A.J., Rothbaum, B.O., Klein, D.N., Trivedi, M.H., Manber, R., Keller, M.B., Leon, A.C., Wisniewski, S.R., Arnow, B.A., Markowitz, J.C., & Thase, M.E. (in press). Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and Brief Supportive Psychotherapy for augmentation of antidepressant nonresponse in chronic depression: A randomized controlled trial. Archives of General Psychiatry.
Current Research Support:
National Institute of Mental Health (UO1 MH062546), "CBASP augmentation for treatment of chronic depression."
2002 - 2009. $1,058,320 (direct costs)
Daniel Klein (Principal Investigator)
National Institute of Mental Health (RO1 MH 069942), "Temperamental low PE in preschoolers and depression risk."
2004 - 2010. $2,343,562 (direct costs)
Daniel Klein (Principal Investigator)
National Institute of Mental Health (RO3 MH 082113), "Error-related brain activity and risk for anxiety and depressive disorders."
2008 - 2010. $99,887 (direct costs)
Greg Hajcak (Principal Investigator); Daniel Klein (Co-Investigator)
