Daniel Klein, Ph.D.
State University of New York at Buffalo (1983)
Professor, Clinical Psychology
Office: Psychology B-444
Office Hours: Flexible, by appointment
Phone Number: (631) 632-7859

Web site for Stony Brook temperament study:
Areas of Interest:
Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.

Current Research:
Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children. The children were assessed at ages 3, 6, and 9; assessments at age 12 and 15 are currently being planned. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, executive functioning, psychopathology, psychophysiological and behavioral measures of biases in processing emotional information, susceptibility genes, stress and pubertal hormones, parenting, environmental and family stress, and parental personality and psychopathology. In addition, resting state and task-related functional magnetic resonance imaging (fMRI) measures are being collected on a subset of the larger sample

Dr. Klein is also continuing to work with data sets from several past studies, including several multi-site clinical trials of the treatment of chronically depressed adults; a family and follow-up study of chronically depressed adult outpatients; and a family and follow-up study of a large community sample of adolescents.

Awards and Recognition:
Sustained Mentor Award, Society for Research on Psychopathology, 2012

Award for Distinguished Scientific Contributions to Clinical Psychology, Society of Clinical Psychology (Division 12 of the American Psychological Association), 2012

Ranked 27th in overall productivity and 13th in peer reviewed publications among 1,927 core faculty in accredited Clinical Psychology doctoral programs (Stewart, Wu, & Roberts [2007]. Top producers of scholarly publications in Clinical Psychology PhD programs. Journal of Clinical Psychology, 63, 1209-1215).

President, Society for a Science of Clinical Psychology (SSCP) (Section III, Division 12 of the American Psychological Association), 2007

President, Society for Research in Psychopathology (SRP), 2003

Dean’s Award for Excellence in Graduate Mentoring by a Faculty Member, Stony Brook University, 2003

Joseph Zubin Memorial Award, Research Foundation for Mental Hygiene, New York State Psychiatric Institute and Western Psychiatric Institute and Clinic, 2000

Selected Recent Publications:
Bress, J.N., Foti, D., Kotov, R., Klein, D.N., & Hajcak, G. (2013). Blunted neural response to rewards prospectively predicts depression in adolescent girls. Psychophysiology, 50, 74-81.

Danzig, A.P., Bufferd, S.J., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2013). Longitudinal associations between preschool psychopathology and school-age peer functioning. Child Psychiatry and Human Development, 44, 621-632.

Dougherty, L.R., Smith, V.C., Bufferd, S.J., Stringaris, A., Leibenluft, E., Carlson, G.A., & Klein, D.N. (2013). Preschool irritability: Associations with psychiatric disorders at age six and parental psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 521303-1313.

Dougherty, L.R., Smith, V., Olino, T.M., Dyson, M., Bufferd, S., Rose, S., & Klein, D.N. (2013). Maternal depression and early child temperament predict young children’s salivary cortisol three years later. Journal of Abnormal Child Psychology, 41, 531-542.

Dougherty, L.R., Tolep, M.R., Bufferd, S.J., Olino, T.M., Dyson, M.W., Traditi, J., Rose, S., Carlson, G.A., & Klein, D.N. (2013). Preschool anxiety disorders: Comprehensive assessment of clinical, demographic, temperamental, familial, and life stress correlates.Journal of Clinical Child and Adolescent Psychology, 42, 577-589.

Hayden, E.P., Hanna, B., Sheikh, H.I., Laptook, R.S., Kim, J., Singh, S.M., & Klein, D.N. (2013). Child dopamine active transporter I genotype and parenting: Evidence for evocative gene-environment correlations. Development and Psychopathology, 25, 163-173.

Hayden, E.P., Olino, T.M., Bufferd, S.J., Miller, A., Dougherty, L.R., Sheikh, H.I., Singh, S.M., & Klein, D.N. (2013). The 5-HTTLPR and BDNF Val66Met polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood. Development & Psychopathology, 25, 587-598.

Klein, D.K., Glenn, C.R., Kosty, D.B., Seeley, J.R., Rohde, P., Lewinsohn, P.M. (2013). Predictors of first lifetime onset of major depressive disorder in young adulthood. Journal of Abnormal Psychology, 122, 1-6.

Klein, D.N., Kujawa, A.J., Black, S.R., & Pennock, A.T. (2013). Depressive disorders. In T.P. Beauchaine and S.P. Hinshaw (Eds.), Child and adolescent psychopathology, 2nd ed. (pp. 543-576). Hoboken, New Jersey: John Wiley & Sons.

Kryski, K.R., Dougherty, L.R., Sheikh, H.I., Dyson, M.W., Olino, T.M., Laptook, R.S., Singh, S.M., Klein, D.N., & Hayden, E.P. (2013). Effortful control, and parenting: Associations with HPA axis reactivity in early childhood. Developmental Science, 16, 531-541.

Kujawa, A.J., Klein, D.N., & Hajcak, G. (2013). Two-year stability of the late positive potential across middle childhood and adolescence. Biological Psychology, 94, 290-296.

Kujawa. A.T., Weinberg, A., Hajcak, G., & Klein, D.N. (2013). Differentiating event-related potential components sensitive to emotion in middle childhood: Evidence from temporal-spatial PCA. Developmental Psychobiology, 55, 539-550.

Meyer, A., Hajcak, G., Torpey, D.C., Kujawa, A., Kim, J., Bufferd, S., Carlson, G., & Klein, D.N. (2013). Increased error-related brain activity in six-year- old children with clinical anxiety. Journal of Abnormal Child Psychology, 41, 1257-1266.

Olino, T.M., Durbin, E.C., Klein, D.N., Hayden, E.P. & Dyson, M.W. (2013). Gender differences in young children’s temperament traits: An observational study. Journal of Personality, 81, 119-129.

Pettit, J.W., Hartley, C., Lewinsohn, P.M., Seeley, J.R., & Klein, D.N. (2013). Is liability to recurrent major depressive disorder present before first episode onset in adolescence or acquired after the initial episode? Journal of Abnormal Psychology 122, 353-358.

Rohde, P., Lewinsohn, P.M., Klein, D.N., Seeley, J.R., & Gau, J.M. (2013). Key characteristics of major depressive disorder occurring in childhood, adolescence, emerging adulthood, and adulthood. Clinical Psychological Science, 1, 41-53.

Sheikh, H.I., Kryski, K.R., Smith, H.J., Dougherty, L.R., Klein, D.N., Bufferd, S.J., Singh, S.M., & Hayden, E.P. (2013). Catechol-O-Methyltransferase gene val158met polymorphism and depressive symptoms during early childhood. American Journal of Medical Genetics Part B, B164, 245-252.

Steidtmann, D., Manber, R., Blasey, C., Markowitz, J.C., Klein, D.N., Rothbaum, B.O., Thase, M.E., Kocsis, J.H., & Arnow, B.A. (2013). Detecting critical decision points in psychotherapy and psychotherapy + medication for chronic depression. Journal of Consulting and Clinical Psychology, 81, 783-792.

Torpey, D.C., Hajcak, G., Kim, J., Kujawa, A.J., Dyson, M.W., Olino, T.M., & Klein, D.N. (2013). Error-related brain activity in young children: Associations with parental anxiety and child temperamental negative emotionality. Journal of Child Psychology and Psychiatry, 54, 854-862.

Carlson, G.A., & Klein, D.N. (in press). How to understand divergent views on bipolar disorder in youth. Annual Review of Clinical Psychology.

Dougherty, L.R., Smith, V.C., Bufferd, S.J., Carlson, G.A., Stringaris, A., Leibenluft, E., & Klein, D.N. (in press). DSM-5 Disruptive Mood Dysregulation Disorder: Correlates and predictors in young children. Psychological Medicine.

Kujawa, A.J., Dougherty, L.R., Durbin, C.E., Laptook, R.S., Torpey, D.C., & Klein, D.N. (in press). Emotion recognition in preschool children: Associations with maternal depression and early parenting. Development and Psychopathology.

Current Research Support:
National Institute of Mental Health (RO1 MH 069942), "Temperamental emotionality in preschoolers and depression risk."
2004 - 2019. $6,789,330 (direct costs)
Principal Investigator

National Institute of Mental Health (RO1 MH 097767), “Trajectories of reward sensitivity and depression across adolescence”.
2012-2017. $1,250,000 (direct costs).
Co-Investigator (PI: Greg Hajcak Proudfit)

National Institute of Mental Health (RO1 MH 093479) “Personality development and vulnerability to first-episode depression”.
2012-2017. $1,789,347 (direct costs).
Co-Investigator (PI: Roman Kotov)

National Institute of Mental Health (RO3 MH 094518), “Reward-related brain activity:
Biomarker for risk of depression in childhood”
2011-2013. $100,000 (direct costs).
Co-Investigator (PI: Greg Hajcak)

National Institute of Mental Health (RO1 MH098093), “Family study of reward and threat sensitivity in internalizing psychopathology”
2012-2016 $1,970,349 (direct costs)
Co-Investigator (PI: Stewart Shankman)